Selected Publications 

 

 

Schreij AMA*, Chaineau M, Ruan W, Lin S, Barker, PA, Fon EA§, McPherson PS§. LRRK2 localizes to endosomes and interacts with clathrin-light chains to limit Rac1 activation. EMBO Rep. 2015; 16(1):79-86. §co-corresponding authors [link]

Grenier K*, Kontogiannea M*, Fon EA. Short mitochondrial ARF triggers Parkin/PINK1-dependent mitophagy in neurons. J. Biol. Chem. 2014; 289(43):29519-30 [link]

Durcan TM*, Tang MY*, Pérusse JR, Dashti EA*, Aguileta MA*, McLelland GL*, Gros P*, Shaler TA, Faubert D, Coulombe B, Fon EA. USP8 Regulates Mitophagy by Removing K6-linked Ubiquitin Conjugates from Parkin. EMBO J. 2014; 33(21):2473-91 [link]

Sugiura A, McLelland GL*, Fon EA, McBride HM. A new Pathway for Mitochondrial Quality Control: Mitochondrial Derived Vesicles. EMBO J. 2014; 33(19):2142-2156 [link]

Koyano F, Okatsu K, Kosako H, Tamura Y, Go E, Kimura M, Kimura Y, Tsuchiya H, Yoshihara H, Hirokawa T, Endo T, Fon EA, Trempe JF, Saeki Y, Tanaka K, Matsuda N. Ubiquitin is phosphorylated by PINK1 to activate parkin. Nature. 2014; 510(7503):162-6 [link]

McLelland GL*, Soubannier V, Chen CX*, McBride HM, Fon EA. Parkin and PINK1 Function in a Vesicular Trafficking Pathway Regulating Mitochondrial Quality Control. EMBO J. 2014; 33(4):282-95. [link]

Bertolin G, Ferrando-Miguel R, Jacoupy M, Traver S, Grenier K*, Greene AW*, Dauphin A, Waharte F, Bayot A, Salamero J, Lombès A, Bulteau AL, Fon EA, Brice A, Corti O. The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN-dependent mitochondrial clearance. Autophagy. 2013; 9(11):1801-17 [link]

Grenier K*, McLelland GL*, Fon EA. Parkin- and PINK1-Dependent Mitophagy in Neurons: Will the Real Pathway Please Stand Up? Front Neurol. 2013; 4:100 [link]

Trempe J-F*, Sauvé, V*, Grenier K, Seirafi, M, Tang MY, Ménade M, Krett J, Wong K, Kozlov G, Nagar B, Fon EA§, Gehring K§. Structure of parkin reveals mechanism of ubiquitin ligase activation. Science. 2013; 340: 1451-55 Epub 2013 May 9. §co-corresponding authors.  [pdf]   [abstract]

Durcan TM*, Fon EA. Ataxin-3 and its E3 partners: Implications for Machado-Joseph disease.  Front. Neur. 2013 4:46. [link]

Trempe JF*, Fon EA. Structure and function of parkin, PINK1 and DJ-1, the three musketeers of neuroprotection.Front. Neur. 2013. 4:38. [link]

Ruan W*, Unsain N, Desbarats J, Fon EA§, Barker PA§. Wengen, the Sole Tumour Necrosis Factor Receptor in Drosophila, Collaborates with Moesin to Control Photoreceptor Axon Targeting During Development. PLoS One2013; 8(3): e60091. §co-corresponding author [link]

Daoud H, Noreau A, Rochefort D, Paquin-Lanthier G, Gauthier MT, Provencher P, Pourcher E, Dupré N, Chouinard S, Jodoin N, Soland V, Fon EA, Dion PA, Rouleau GA. Investigation of C9orf72 repeat expansions in Parkinson's disease. Neurobiol Aging. 2013 Jun; 34(6): 1710.e7-9. doi: 10.1016/j.neurobiolaging.2012.11.025 [link]

Grimes D, Gordon J, Snelgrove B, Lim-Carter I, Fon E, Martin W, Wieler M, Suchowersky O, Rajput A, Lafontaine AL, Stoessl J, Moro E, Schoffer K, Miyasaki J, Hobson D, Mahmoudi M, Fox S, Postuma R, Kumar H, Jog M; Canadian Neurological Sciences Federation. Canadian Guidelines on Parkinson's Disease. Can J Neurol Sci. 2012 Jul;39 (4 Suppl 4):S1-30 [link]

Klionsky DJ et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr;8(4):445-544 [link]

Greene AW*, Grenier K*, Aguileta MA, Muise S, Farazi R, Haque ME, McBride HM, Park DS, Fon EA. Mitochondrial Processing Peptidase Regulates PINK1 Processing, Import and Parkin Recruitment. EMBO Rep. 2012; 13(4):378-85 [link]

Soubannier V, McLelland GL, Zunino R, Braschi E, Rippstein P, Fon EA, McBride HM. A novel vesicular transport pathway shuttles cargo from mitochondria to lysosomes. Curr. Biol. 2012; 22(2):135- [link]

Durcan TM, Kontogiannea M, Bedard N, Wing SS, Fon EA. Ataxin-3 deubiquitination is coupled to parkin ubiquitination via the E2 ubiquitin-conjugating enzyme. J. Biol. Chem. 2012; 287(1):531-41 [link]

Durcan TM, Fon EA. Mutant ataxin-3 promotes the autophagic degradation of parkin. Autophagy. 2011; 7(2):233-4 [link]

Durcan TM*, Kontogiannea M*, Thorarinsdottir T, Fallon L, Williams AJ, Djarmati A, Fantaneanu T, Paulson HL, Fon EA. The Machado-Joseph Disease-Associated Mutant form of Ataxin-3 Regulates Parkin Ubiquitination and Stability. Hum. Mol. Genet. 2011; 20(1):141-54 [link]

Irrcher I, Aleyasin H, Seifert EL, Hewitt SJ, Chhabra S, Phillips M, Lutz AK, Rousseaux MW, Bevilacqua L, Jahani-Asl A, Callaghan S, Maclaurin JG, Winklhofer KF, Rizzu P, Rippstein P, Kim RH, Chen CX, Fon EA, Slack RS, Harper ME, McBride HM, Mak TW, Park DS. Loss of the Parkinson's Disease-linked gene DJ-1 perturbs mitochondrial dynamics. Hum. Mol. Genet. 2010; 19(19):3734-46 [link]

Théard D, Labarrade F, Partisani M, Milanini J, Sakagami H, Fon EA, Wood SA, Franco M, Luton F. USP9x-mediated deubiquitination of EFA6 regulates de novo tight junction assembly. EMBO J. 2010;29(9):1499-509 [link]

Bouvier D, Tremblay ME, Riad M, Corera AT, Gingras D, Horn KE, Fotouhi M, Girard M, Murai KK, Kennedy TE, McPherson PS, Pasquale EB, Fon EA, Doucet G. EphA4 is localized in clathrin-coated and synaptic vesicles in adult mouse brain. J. Neurochem. 2010; 113:153-165 [link]

Trempe JF*, Chen CXQ*, Grenier K, Camacho EM, Kozlov G, McPherson PS, Gehring K, Fon EA. SH3 Domains from a Subset of BAR-Proteins Define a Novel Ubl-Binding Domain and Implicate Parkin in Synaptic Ubiquitination. Mol. Cell 2009; 36(6):1034-47. Co-corresponding authors [link]

Corera AT, Doucet G, Fon EA. Long-Term Potentiation in Isolated Dendritic Spines. PLoS ONE. 2009; 4(6): e6021. doi:10.1371/journal.pone.0006021. [link]

Cookson MR, Dauer W, Dawson TM, Fon EA, Guo M, Shen J. The roles of kinases in familial Parkinson’s disease. J. Neurosci. 2007; 27(44):11865-8 [link]

Kaiser P, Fon EA. Keystone Meeting on Ubiquitin and Signaling: Expanding Horizons at Big Sky. EMBO Rep. 2007; 8(9):817-22. [link]

Joch M*, Ase AR*, Chen CXQ*, MacDonald PA, Kontogiannea M, Corera AT, Brice A, Séguéla P, Fon EA. Parkin-Mediated Monoubiquitination of the PDZ Protein PICK1 Regulates ASIC Channel Activity. Mol. Biol. Cell. 2007; 18(8):3105-18[link]

Zhou L, Martinez SJ, Haber M, Jones EV, Bouvier D, Doucet G, Corera AT, Fon EA, Zisch AH, Murai KK. EphA4 signaling regulates phospholipase Cgamma1 activation, cofilin membrane association, and dendritic spine morphology. J. Neurosci. 2007; 27(19):5127-38.[link]

Fallon L, Bélanger CML, Corera AT, Kontogiannea M, Regan-Klapisz E, Moreau F, Voortman J, Haber M, Rouleau G, Thorarinsdottir T, Brice A, van Bergen en Henegouwen P, Fon EA. A Regulated Interaction with the UIM-protein Eps15 Implicates Parkin in EGF Receptor Trafficking and PI3K-Akt Signaling.Nat. Cell Biol. 2006; 8(8):834-42 [link]

 Kalia SK, Lee S, Liu L, Crocker SJ, Thorarinsdottir TE, Smith PD, Glover JR, Fon EA, Park DS, Lozano AM. BAG5 inhibits parkin and enhances dopaminergic neuron degeneration. Neuron 2004; 44(6):931-45. [link]